Shiitake Mushroom,
The Gourmet and Medicinal Variety


Shiitake mushroom is by far one of the world's most popular edible mushroom species. Known for its rich and robust flavor, it is used extensively in East Asian foods and cherished among gourmet chefs around the globe for it's attractive culinary features. 

Although prized for its superior taste and texture, it is also a potent medicinal mushroom variety and immune system modulator. Comprised of beta-glucans and other polysaccharides, such as lentinan, emitanin and KS-2, the mycelium has been extensively researched for it's potential pharmacological actions.

Definitely the most studied extracts of the mycelium are the two preparations called LEM (Lentinus edodes mycelial extract) and lentinan, both of which demonstrate powerful antitumor activities.

Shiitake's have been utilized by humans for thousands of years. Most well-known in their native habitat locations in regions of China, Japan and Korea, the mycelium has been a long revered food source as well as an age-old folk remedy for many ailments from the common cold to inflammatory related conditions.

In Traditional Chinese Medicine, the mushroom is identified as a food that has an "upward" movement on the "yang" energy of the body and is especially helpful for disorders associated with the lower body region. Often recommended for weak digestive systems, it is classified as having a "sweet flavor" which corresponds to the stomach and spleen meridians and organs. Referred to as hsiang ku in Chinese, a word describing it's fragrant aroma, the mushroom is customarily used as a circulatory system regulator believed to "activate the blood" as well as neutralize the toxic influences.

Shiitake mushroom, consumed as a food or supplement, has shown to have positive effects on reducing LDL cholesterol via the amino acid constituent eritadenine. In Japan and China it is also known to be helpful for reducing the risk of stroke and is a commonly prescribed treatment for high blood pressure.

Pronounced "she-tah-key", the mushroom is one of the most popular cultivated varieties next to Agaricus bisporus or white button mushrooms. Found fresh or dried in markets worldwide, shiitake is one of the most convenient medicinal species to use over others, like chaga or coriolus, which in fact exhibit much stronger antitumor attributes, but are not normally as suitable for culinary purposes.

Shiitake is an exquisite tasting mushroom and easy to use in many recipes. It is especially beneficial when heated in water or soups. This helps to release and concentrate the polysaccharide myco-nutrients into the liquid broth.

For increased medicinal potency, it is also frequently consumed as a dietary supplement or hot water extract, usually produced from either the whole fruiting body, the mycelium biomass or isolated bioactive constituents, as is the case with the lentinan extracts.

Not only is the mycelium valued for its anticarcinogenic properties, but it is additionally effective as a natural anti-inflammatory, anitbiotic and antiviral agent. Both strengthening and restorative, shiitake is a recognized nutritional supplement for improving autoimmune disorders and is particularly healing for those with chronic fatigue syndrome. It is also therapeutically used to treat other depressed immune conditions such as AIDS, hepatitis, herpes, allergies, candida overgrowth as well as influenza or the common cold.


What is Shiitake Mushroom?

Shiitake (Lentinus edodes) is native to East Asian countries, where it has been wild harvested and extensively cultivated as a common edible mushroom variety, often prepared with daily meals and miso soups.

Lentinus edodes is a wood-decaying fungus, growing wild on deciduous tree species like chestnut, oak, maple, beech and mulberry. Preferring warm and moist climate zones, shiitake typically flushes in groups rather than as a isolated mycelium species.

Originally cultivated using ancient shiitake growing methods, usually on hardwood logs, the mushroom is now widely propagated for commercial use on natural wood pulp, a rice medium or artificial substrate, and less frequently on cut tree logs.


Shiitake Mushroom Benefits

Immune Modulating Polysaccharides with Antitumor Effects

Shiitake mushroom contains a number of polysaccharides with beneficial effects as immune system modulators and "host defense potentiators." The three most well-known of these myco-constituents are lentinan, emitanin and KS-2.

Lentinan, first isolated from Lentinus edodes in 1969, is a beta-glucan polysaccharide that significantly boosts immune response by inducing the body's production of interferon. Interferons are signaling proteins that are released by host cells to defend against and eliminate pathogenic substances. The word interferon comes from the word "to interfere" as it disrupts the continued growth of harmful viruses, tumor cells, parasites or bacteria. Interferons also stimulate other immune cells and is part of the reason lentinan has been shown to promote NK cell and white blood cell activity, an effect that is largely responsible for suppressing tumor growth.

Research investigating the anticancer properties of shiitake mushrooms has been ongoing since at least the 1960's. In this research, lentinan has been the most frequently studied compound found in shiitake or L. edodes mushroom.

Lentinan was approved as a pharmaceutical drug and antitumor agent in Japan in 1985 for use as an adjunct in cancer therapy to suppress secondary tumor formation. Likewise, lentinan is used by many present-day medical professionals to boost the effects of medications used for treating cancer and HIV infection. Usually it is given intravenously or as an injection.

Lentinan extract has been used in pharmacological blends along with other tonic herbs and mushroom extracts, also known to stimulate white blood cells. The three most common of which include reishi, astragalus root and PSK, the active ingredient in coriolus mushroom.

Similar to lentinan, Lentinus edodes mycelial extract (LEM) has additionally shown in some research to have usefulness in the treatment of AIDS by inhibiting viral infection and replication.

Shiitake mushroom has repeatedly demonstrated effectiveness for treating gastric cancer or colon cancer when used in combination with chemotherapy. (Source)  In a 2015 study published in the journal Surgical Oncology it states, "Lentinan combined with gemcitabine chemotherapy significantly inhibited urothelial bladder cancer cell proliferation."

In 1977, the shiitake-derived polysaccharide emitanin was patented for use as an anticancer agent and one year later the new polysaccharide, called KS-2, was extracted from Lentinus edodes and exhibited antitumor activity in cancerous mice. KS-2 was additionally shown to suppress tumor growth via it's immune modulating effects that, like lentinan, also helped to stimulate the production of interferon. (Source)


Simmered fresh shiitake as well as the powders and extracts, although not as concentrated, do contain lentinan and other polysaccharide compounds in high amounts. Several studies using the whole dried fruiting body powder have proven significant immune stimulating properties and macrophage phagocytosis, the process by which white blood cells engulf cancer cells.

Good for Chronic Fatigue and Candida Overgrowth

The lentinan derived from shiitake has been known to aid in the treatment of other autoimmune disorders including chronic fatigue syndrome. In the book "Shiitake: The Healing Mushroom", Kenneth Jones dedicates an entire chapter to shiitake and its benefits for CFS.

It was discovered over a decade ago that those with chronic fatigue syndrome also appear to have extremely low levels of NK cell activity. In one 2010 study entitled "Biomarkers in chronic fatigue syndrome: evaluation of natural killer cell function", evidence demonstrated that people with chronic fatigue syndrome have decreased function and abnormal activation of NK cells. As we mentioned, shiitake mushroom induces the production of interferon, which helps to stimulate NK cell activity.

Although many of the popular edible mushrooms are not recommended for those with candida overgrowth, shiitake and other medicinal varieties do not encourage the development of fungal yeast strains, but in fact help to reestablish beneficial microflora through building immune response.

Shown to Reduce Cholesterol and Help Prevent Obesity

According to research studies, a compound isolated in the mushroom called eritadenine has shown to have cholesterol-lowering effects when tested on rats consuming a high fat diet. Various other scientific investigation indicates that these effects can be achieved by consuming both dried concentrations or extracts as well as the whole shiitake mushroom caps and stems, all of which deliver therapeutic amounts of eritadenine to greater or lesser degrees depending on how they are prepared. (Source

The eritadenine is believed to lower blood levels of cholesterol and lipids by blocking the way it is absorbed into the bloodstream and thus diverts it to the liver where it can be further processed. This is beneficial for those with cardiovascular disease with conditions like atherosclerosis or plaque build-up in the blood.

In other more recent studies, low to medium doses of shiitake powder were demonstrated to be a functional supplement for preventing obesity and related metabolic disorders by also inhibiting fat deposition as well as plasma triglycerides.

Contains the Anti-Inflammatory Ergothioneine

All forms of shiitake mushroom, powder and extracts contain the anti-inflammatory amino acid "ergothioneine." This bioactive compound has been proven to be especially effective for reducing the inflammation related to atherosclerotic cardiovascular disease as demonstrated in the 2015 study entitled, "Ergothioneine represses inflammation and dysfunction in human endothelial cells exposed to oxidized low-density lipoprotein."


Good for High Blood Pressure

Shiitake, as well as reishi and maitake, have shown to be beneficial in reducing high blood pressure through its LDL cholesterol-lowering properties. According to the book entitled Shiitake: The Healing Mushroom, "In Japan there are modern-day accounts of high blood pressure normalizing or being substantially lowered from eating eight mushrooms a day for a couple of weeks."

In one study investigating the effects of maitake and shiitake on hypertensive rats, results indicated a decrease in cholesterol levels as well as a reduction in blood pressure.

Shiitake Mushroom's Nutrition

Shiitake mushrooms are naturally high in certain vitamins, minerals, dietary fiber and amino acids. This includes Vit. D, B vitamins, Vit. K, copper, selenium, pantothenic acid with high amounts of iron in the caps and zinc in the stems. 

The mushroom contains the antioxidant substance called thioproline, known to be helpful in removing nitrites or nitrosamine preservatives found in some food products.

Shiitake, as well as other mushrooms, are considered one of the best dietary sources of germanium, a natural dextofier and immune booster.

According to Nutritional Data, a four mushroom serving has the highest amounts of:

  • Copper - 32% DV
  • Selenium - 26% DV
  • Pantothenic Acid - 26% DV

Growing Shiitake Mushrooms

One of the great things about shiitake is that they are relatively easy to grow indoors on a mushroom growing log or cake. Shiitake's are prolific and inexpensive to cultivate at home with a mushroom growing starter kit.

The shiitake mushroom also makes an excellent log growing variety for incorporating into outdoor permaculture design. They can be used to speed up log decomposition, which will later feed the soil, whilst providing an abundant food source simultaneously.

For more information on how to grow shiitake check out the following books:


Types of Shiitake

  1. Fresh Mushroom Fruiting Body - The whole cultivated, wild or home grown fresh mushroom.
  2. Dried Fruiting Body - The dried whole mushroom, mushroom slices or powder that can be reconstituted or prepared in hot liquids.
  3. Hot Water Extracts - These are primarily created from the fruiting body or mycelium biomass; available in powder or capsule form.
  4. Standardized Extracts - Lab produced extracts composed of standard ratios of certain active constituents like lentinan. Extracts of the active compounds are mainly sold in Japan.

How to Use

It is important to eat nutritious whole foods and superfoods that keep the immune system functioning optimally so we can prevent major health issues further down the road. Shiitake is an easy food to integrate into the diet on a regular basis to assist in attaining this goal.

Although some of the other medicinal mushrooms have been proven to exhibit stronger antitumor and immune boosting effects, shiitake is widely available and more familiar to most people. Fresh mushrooms can usually be found in the produce sections of most markets and easier to incorporate into meals and recipes than mushrooms like chaga, coriolus and reishi mushroom.

Maitake is another extremely beneficial medicinal that is close to shiitake in texture and flavor. It is becoming more common to find fresh maitake in supermarkets along side other less medicinal variety's like oyster, crimini, or portabella.


Simmering Fresh Shiitake in Liquid

Shiitake mushrooms can be eaten raw like other store bought varieties, but can cause digestive disturbance for some individuals such as flatulence and abdominal bloating. Generally, we don't recommend consuming them in their raw state as all medicinal mushroom varieties need to be heated, preferably simmered in water as a liquid broth, to release their polysaccharide-rich nutrients.

They can also be sautéed, steamed or baked with other foods as well as prepared in soups or with grains like our two favorites, quinoa or wild rice.

As another alternative to heating the actual mushroom, marinating and dehydrating shiitake does help to soft the fibers and increases the nutritional value. The raw mushroom is also more digestible when finely processed into recipes rather than chopped or sliced. These preparation techniques are often used by those adhering to a raw food diet.

The mushroom goes well in miso soup, accompanied with seaweeds, and is delicious when prepared in tempeh recipes.

For our website recipes using shiitake mushroom visit the following page links:

Medicinal Mushroom Extracts

The best and most medicinally effective way to use this mushroom is to consume the hot water extracts in powder or capsule form. For greatest health benefits we advise consuming both the mushroom and extracts simultaneously.


Generally, shiitake has no toxic effects when ingested and is considered a safe food to consume on a regular basis. On very rare occasions, however, some people experience a toxic reaction to the raw mushroom which causes a skin outbreak called shiitake dermatitis. In addition, those with allergies to mushrooms should avoid ingesting. Consult your health care provider before taking shiitake extracts, especially if you have serious medical conditions or are taking prescription medications.

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